Pyridoxal-5-phosphate (P-5-P) is the bioactive form of vitamin B6 found in our bodies.
What's it up to?
It is required for the synthesis of several neurotransmitters, including serotonin (for appetite, sleep, and mood), dopamine (involved in the regulation of blood pressure and heart rate), and GABA (a neurotransmitter that blocks impulses between nerve cells in the brain).
Though it is not a methyl donor like vitamin B9 (methylfolate) and B12 (methylcobalamin), P-5-P is necessary for homocysteine recycling. This is the change back into methionine using vitamin B12-related enzymes, keeping homocysteine lower. Elevated homocysteine levels affect the interior lining of blood vessels in the body or narrowing of blood vessels.