Methylfolate is the methylated form of vitamin B9—the form your body actually uses. By using methylfolate instead of folic acid, you can bypass the pathway that changes folic acid to methylfolate.
Folic acid → dihydrofolate → tetrahydrofolate → 5,10 methylene THF → methylfolate
If you have the MTHFR gene variant, you may have a difficult time making the enzyme that converts folic acid to methylfolate. You must take methylfolate. Even if you don’t have the MTHFR gene variant, the benefits of taking methylfolate are numerous.