Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the reduced and active form of folate. It delivers a "finished" folate the body can immediately use without any kind of metabolization.
No conversion needed
Folic acid and also food folate are not biologically active and need to be converted to the metabolically active 5-MTHF through a multi-steps process where the enzyme methylenetetrahydrofolate reductase (MTHFR) owns a key role. Some individuals, due to their unique genetic patterns and expression, have polymorphic forms of this enzyme and have an impaired ability to produce an adequate or effective amount of MTHFR.
Higher folate uptake
The other advantage of Quatrefolic is that it is the biologically active form (1). It can enter the folate cycle directly. There is no unmetabolized folic acid with Quatrefolic for a safe and full active folate efficacy (2). It passes the gastric barrier and is absorbed mainly in the small intestine by a carrier mediated mechanism. The carrier is not saturated and this enables Quatrefolic to ensure a higher folate uptake (3).